By real-time PCR Kong et al. identified six genes (COL1A1, COL3A1, CRABP2, FLG, TGM1, and TGM3) that respond to RA and RO stimulation in human skin, none of which were DE in LMH cells, which were derived from chicken liver carcinoma. The gene discussed is FLG; the disease is hepatocellular carcinoma.