Gene-modified NK cells with chimeric antigen receptor (CAR) have been shown to enhance the effector cell function and antigen-specificity against several tumor targets, including anti-CD19 CAR-NK for targeting and chronic lymphocytic leukemia (CLL) [9] and anti-CD138 CAR-NK for targeting multiple myeloma patients [10]. The gene discussed is CD19; the disease is B-cell chronic lymphocytic leukemia.