Finally, it would be helpful to mention that ischemic stroke may be the initial manifestation of hematologic diseases and also that both inherited (such as factor V Leiden and prothrombin G20210A mutations, deficiencies of protein C, protein S and anti-thrombin) and acquired hypercoagulable disorders (notably anti-phospholipid syndrome and neoplastic thrombophilia) may be a commonly unrecognized cause of ischemic stroke, particularly in young patients [56,57,58]. This evidence concerns the gene PROS1 and ischemic stroke.