The effect of RESV, PRI-2191, and their combination on the secretion of VEGF, OPN, and IL-8 by A549, HCC827, and NCI-H358 tumor cells was tested using enzyme-linked immunosorbent assay (ELISA) in conditioned medium, while the level of PD-L1 was analyzed in cell lysates. The gene discussed is CXCL8; the disease is neoplasm.