UBE3B and autosomal recessive disease: An independent splice site variant in bovine UBE3B is associated with an autosomal-recessive inherited disorder called PIRM syndrome in Finnish Ayrshire cattle, which causes intellectual disability, retarded growth, and mortality (OMIA 001934-9913) [45], and which resembles the human autosomal-recessive Kaufman oculocerebrofacial syndrome (OMIM 244450) [46].