INS and fatty liver disease: In a small randomized, cross-over trial enrolling 12 non-diabetic patients with biopsy-proven NAFLD, randomly assigned to Mediterranean diet or low fat-high carbohydrate diet over a follow-up of 6 weeks, Ryan et al. reported that the Mediterranean diet reduced liver steatosis (−39% vs. −7%, as measured by magnetic resonance spectroscopy, p < 0.05) and improved insulin sensitivity [31].