LOXL2 and metabolic dysfunction-associated steatohepatitis: However, in two phase 2b trials of 219 patients with bridging fibrosis caused by NASH (median age 57 years; approximately 68% with established T2DM) who were randomly assigned to groups given weekly subcutaneous injections of simtuzumab (a monoclonal antibody against LOXL-2) or placebo for 240 weeks, Harrison et al. reported that simtuzumab was ineffective in decreasing hepatic collagen content and hepatic venous pressure gradient [82].