AKT1 and myocardial infarction: Early studies showed that statin treatment was associated with decrease in myocardial infarction size through the PI3K/Akt pathway and “reperfusion injury salvage kinase” (RISK) pathway [56], but this was not confirmed in preclinical and clinical studies because of insufficient compound targeted to the infarcted area in case of systemic (untargeted) administration [57,58].