Indeed, GFAP and Cd11b indicated a glial response to retinal degeneration in Müller glia processes and the activation of microglia cells, respectively, as opposed to Rd1 wt retinas at p13, which showed no GFAP reactivity in Müller glia processes and only a weak signal of the pan-microglia marker ionized calcium binding adaptor molecule 1 (Iba1) (Figure 1B). This evidence concerns the gene PDE6B and retinal degeneration.