NIPAL4 and autosomal recessive congenital ichthyosis: [31] In order to examine Nipal4-mediated ARCI, Honda and colleagues developed a transgenic mouse model of Nipal4-KO mice (Nipal4−/−), demonstrating a significant increase of TEWL in the knockout mice compared to Nipal4+/+ and Nipal4+/− control animals [32].