Eckl et al. investigated different forms of autosomal recessive congenital ichthyosis (ARCI) in organotypic skin models by individual knock-downs of TGM1 (OMIM #242300), arachidonate lipoxygenase 3 (ALOXE3, OMIM #606545), arachidonate 12-lipoxygenase, 12R Type (ALOX12B, OMIM #242100), NIPA like domain containing 4 (NIPAL4, OMIM #612281), ATP binding cassette subfamily A member 12 (ABCA12, OMIM #601277), and cytochrome P450 family 4 subfamily F member 22 (CYP4F22, OMIM #604777) in primary human keratinocytes [59]. The gene discussed is CYP4F22; the disease is autosomal recessive congenital ichthyosis.