ALOX12B and autosomal recessive congenital ichthyosis: Especially knock-down of TGM1, ALOX12B, and ALOCE3 showed phenotypical alterations comparable to clinical features of ARCI, including thickening of the SC, earlier flattening of keratinocytes, and a more compact structure of the epidermis, suggesting them as useful in vitro models for ARCI.