TREM2 and Peripheral demyelination: Moreover, the TREM2 loss of function in mice treated with the curprizone (CPZ), a CNS demyelination model, induced increasing in the demyelinated lesions and reduced microglia phagocytic activity which was repristinated by TREM2 agonist antibody treatment which promoted the myelin debris removal by microglia and increased remyelination process [114].