These findings confirm that postprandial GLP-1 action is key mediator of postprandial insulin secretion after RYGB and SG; however, whether this increased insulin secretion is fundamental to the improvement in postprandial glucose levels during the early postoperative period in people with T2D is more complex, as multiple other factors may contribute to glucose homeostasis. This evidence concerns the gene INS and type 2 diabetes mellitus.