EGFR and non-small cell lung carcinoma: Following the pivotal phase III randomized trials IPASS and EURTAC, first generation EGFR tyrosine kinase inhibitors (TKIs), gefitinib and erlotinib, demonstrated their superiority in terms of progression-free survival, compared with platinum-based chemotherapy and have been widely adopted as first line treatment NSCLC with EGFR mutations [5,6,7].