LEP and obesity due to melanocortin 4 receptor deficiency: For example, in obesity-sensitive rats, diet supplementation with 60% cooked and dried beans for 26–29 days resulted in reduced fat mass and serum triglyceride concentrations [31], while a seven-week high-fat diet supplemented with cooked red beans (30% wt/wt) lowered the circulating leptin and cholesterol concentrations [33].