SERPINE1 and hydrops fetalis: Conversely, the low-fat weight loss control group (HF→LF) exhibited a different impact on the established obese phenotype, resulting in a reduction in body weight (Figure 1) and circulating concentrations of inflammatory hormones, such as leptin, resistin, and PAI-1, versus the HF and HF→HFB groups (Figure 2); however, there were minimal improvements in intestinal health compared to HF.