Together with the X-linked McLeod syndrome (MLS, OMIM #300842), due to loss-of-function (LOF) variants of the XK gene (*314850), ChAc accounts for the “core” neuroacanthocytosis (NA) syndromes, defined by the combination of RBC acanthocytosis and basal ganglia-related neurological disorders [1,2]. Here, XK is linked to McLeod neuroacanthocytosis syndrome.