Familial ALS can be caused by mutation in several genes, including chromosome 9 open reading frame 72 (C9ORF72) [65], TAR DNA binding protein 43 (TDP-43) [67], the RNA binding protein fused in sarcoma (FUS) [66], superoxide dismutase-1 (SOD1) [88] and Ubiquilin-2 (UBQLN2) [44,89,90]. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.