The CellSearch (Menarini Silicon Biosystems, Bologna, Italy) is the ‘Gold Standard’ platform for CTC isolation and couples immunomagnetic enrichment using ferrofluid coated with anti-EpCAM antibodies with in-device immunostaining for the cancer cell marker cytokeratin (CK) -8, -18 and -19, the leukocyte marker CD45 and nuclear stain 4′,6-diamidino-2-phenylindole (DAPI) [52]. The gene discussed is EPCAM; the disease is cancer.