The classical CIN, observed in 65–70% of sporadic colorectal cancers, is associated with the acquisition of mutations in the adenomatous polyposis coli (APC), mutation of the KRAS oncogene, loss of chromosome 18q and deletion of chromosome 17p, which contains the important tumor suppressor gene TP53 [41]. This evidence concerns the gene APC and cervical squamous intraepithelial neoplasia.