TNF and sporotrichosis: Even though the most severe forms of sporotrichosis (cutaneous-disseminated, and extracutaneous forms with disseminated sporotrichosis, pulmonary sporotrichosis, and several osteoarticular, ocular and CNS disorders) are particularly associated with human immunodeficiency virus (HIV)/AIDS, other underlying diseases or comorbidities associated with immunosuppression, such as diabetes mellitus, malnutrition, drug abuse, chronic alcoholism, steroids, anti-TNF therapy, hematologic cancer and transplanted patients, should be considered [75,88].