To date, the activation of TERT along with the alteration of the CCNA2, CCNE1, MLL4, SERCA1, and PARD6G genes by HBV insertions is among the few recognized early events through which HBV may trigger hepatocarcinogenesis, since these phenomena may occur in the absence of cirrhosis [53,55,56,61,66,102,141] and other oncogenic events such as p53 or CTNNB1 mutations [153]. Here, CCNE1 is linked to Cirrhosis.