As highlighted previously, the HBeAg-negative phase of chronic HBV infection may be associated with different virologic/clinical outcomes including HBeAg-negative chronic infection (serum HBV DNA < 2 × 103 IU/mL and normal ALT) and HBeAg-negative chronic hepatitis (moderate/high serum HBV DNA levels and elevated ALT) characterized by a higher risk of disease progression, the development of cirrhosis, and HCC [15]. This evidence concerns the gene GPT and Cirrhosis.