Indeed, sarco-/endoplasmic reticulum Ca2+ ATPase (which pumps calcium from the cytosol to the endoplasmic reticulum) and PARD6G (the partitioning-defective-6-homolog-gamma gene encoding a protein that is part of the Par6 complex, which is involved in the establishment of cell polarization and in the polarized migration of cells) have been reported in HCC in noncirrhotic HBsAg-negative patients following HBV DNA integration [54,56]. This evidence concerns the gene PARD6G and hepatocellular carcinoma.