The discovery of TENM4 in the human urine [128], in the secretome [129] and in the exosomes [130] of neuroblastoma cell lines might point to a potential role for teneurins as soluble blood and urine tumor biomarkers for non-invasive disease detection and management, at least for the teneurins-overexpressing tumors. Here, TENM4 is linked to neuroblastoma.