TENM2 and ovarian carcinoma: Interestingly, despite the presence of predicted CpG islands in introns from TENM2 genomic regions, the in vitro treatment of ovarian cancer cells with demethylating agents failed to induce the expression of TENM2, suggesting that, at least in ovarian cancer cells, TENM2 down-regulation in aggressive tumors is not related to epigenetic factors.