β-Glucans induce the antimicrobial activity of mononuclear cells and neutrophils as well.13 Regarding T cells, β-glucans help in CD4 + T-cell immunomodulation, allowing them to infiltrate tumors and thereby inhibit tumor growth.15 Orally administered β-glucans can reach the spleen and lymph nodes and significantly reduce tumor burdens by activating DCs, expanding and activating antigen-specific CD4 and CD8 T cells, and inducing IFN-γ production.16 β-Glucans also induce B lymphocytes to produce antibodies. Here, CD4 is linked to neoplasm.