In the tumor, more diversity was observed, including progenitor and terminal exhausted subsets (He et al., 2016; Im et al., 2016; Kurtulus et al., 2019; Miller et al., 2019; Sade-Feldman et al., 2018; Siddiqui et al., 2019; van der Leun et al., 2020), as well as an intermediate-like exhausted subset, naive and/or central memory–like cells, effector-like cells, cycling cells, and IFN-stimulated cells (Fig. 1 C and Table S1; Best et al., 2013; Kakaradov et al., 2017; Milner et al., 2017). This evidence concerns the gene IFNA1 and neoplasm.