CD8A and neoplasm: CD8+ T cells had transcriptional signatures in blood consistent with naive-like, central memory–like, effector-like, and effector memory–like cells and signatures in tumor consistent with diverse exhausted subpopulations, effector-like, resident memory–like, naive-like and/or central memory–like, and cycling populations (Fig. 4, A and B; and Table S8), consistent with previous reports (Guo et al., 2018; Sade-Feldman et al., 2018; Siddiqui et al., 2019; Tirosh et al., 2016; van der Leun et al., 2020; Yost et al., 2019).