Additionally, DE gene analysis on clonally matched populations between blood and tumor showed many effector-like genes up-regulated in TM clones in the blood (e.g., Ccl5, Cx3cr1, Itga4, Runx1, and Klrg1) and exhausted-like genes up-regulated in the blood-matching clones in tumor (e.g., Pdcd1, Lag3, Ctla4, Havcr2, and Tigit; Table S6). This evidence concerns the gene CTLA4 and neoplasm.