Immunohistochemistry staining using CD4 and CD8 antibodies showed a significant increase in CD4+ and CD8+ cells in the joint capsule of both CCL21-Ab and control MMD-knees compared to control sham-operated knees (Fig 10), no positive staining was observed in normal goat serum treated sections that was used as a negative control (S2 Fig). This evidence concerns the gene CD4 and multiminicore myopathy.