Two of the genes evaluated showed elevated protein expression in tumors from IL-6-deficient Eμ-myc mice: BIM [BCL2L11], a BCL-XL and BCL2 interacting mediator of cell death, and PTEN, a phospholipid phosphatase and tumor suppressor gene mutated in many human cancers [Fig 4C]. The gene discussed is PTEN; the disease is cancer.