To determine whether p53 inactivation could accelerate the development of IL6-/-;Eμ-myc lymphomas and produce tumors that are phenotypically similar to those with intact IL-6, we examined lymphoma onset and latency in genetically matched IL6+/+;Eμ-myc;p53+/- and IL6-/-;Eμ-myc;p53+/- mice. This evidence concerns the gene IL6 and lymphoma.