PTEN and lymphoma: Significantly, several of the miRNAs known to target BIM and PTEN [e.g. mmu-miR-18a-3, mmu-miR-92a-2-5p and mmu-miR-92b-3p] are upregulated in IL6+/+;Eμ-myc B cells as compared to their IL6-/-;Eμ-myc counterparts, and presumed to contribute to the BIM and PTEN suppression in IL6+/+;Eμ-myc lymphomas [Fig 4E] [61–64].