One reflection of this dependency in Eμ-myc mice may be seen in the variable time of tumor onset, low rate at which the benign B cells convert to malignancy [~10−10 per cell per generation], and the presence of recurrent mutations in cancer-related genes, such as RAS, TP53 and CDKN2A [28,34,35,57]. This evidence concerns the gene CDKN2A and neoplasm.