CCM2 and famililal cerebral cavernous malformations: Cerebral cavernous malformations are associated with mutations in three genes: CCM1/KRIT1 (krev interaction trapped-1) (MIM#604214), CCM2/MGC4607 (malcavernin) (MIM#607929), and CCM3/PDCD10 (programmed cell death 10) (MIM#609118) (Riant et al. 2010).