However, a recent study, conducted by a 3 T MRI, showed an estimated prevalence of SCCMs, in the familial CCM patients harboring KRIT1 variants, higher than previously reported (approximately 70%), and correlated with patients’ age and number of cerebral cavernous lesions, suggesting that familial CCM is a progressive systemic disease affecting the entire central nervous system (Mabray et al. 2020). The gene discussed is KRIT1; the disease is cerebral cavernous malformation.