In line with this possibility, a pilot, phase IIa, double-blind, randomized, placebo-controlled trial (NCT02790957) conducted in patients with T2D with ischemic wounds showed that mobilization treatment with the CXCR4 antagonist plerixafor had negative effects on wound healing as compared to the placebo, leading to premature trial termination after a pre-planned interim analysis [99]. Here, CXCR4 is linked to type 2 diabetes mellitus.