Considering autophagy plays a dual role in cell death andacrosomal biogenesis, and also, spermatozoa of infertile menwith globozoospermia have low or no acrosome, we aimedto assess the two central markers of autophagy, namely Atg7and LC3II/LC3, as well as the sperm parameters and DNAfragmentation in these individuals. This evidence concerns the gene MAP1LC3A and Globozoospermia.