In this case-control study, 10 semen samples from infertile men with globozoospermia and 10fertile individuals were collected, and the sperm parameters, sperm DNA fragmentation, and main autophagy markers(Atg7 and LC3II/LC3) were assessed according to World Health Organization (WHO) criteria, TUNEL assay, andwestern blot technique, respectively. This evidence concerns the gene ATG7 and Globozoospermia.