TWIST1 and non-small cell lung carcinoma: EMT markers (N-CADHERIN,VIMENTIN, E-CADHERIN and TWIST1) were downregulated in A549 and H1299 cells, whilePVT1 overexpression reversed these effects, indicating thatPVT1 promoted EMT of NSCLC cells through upregulated YAP1 (Fig .5C).Then, we further evaluated their effects on cell migration.