With knowledge of the mechanism of the immuneresponse in sepsis, several immunosuppressionmarkers are proposed, such as the superfamily B7-CD28 called programmed cell death 1 (PD-1) so thatPD1 and programmed death ligand-1 (PD-L1) inhibitthe function of B and T cells (13, 14). This evidence concerns the gene PDCD1 and Sepsis.