Regardless of this, both muscles also had metabolic disorders, (2) an increase in oxidative stress was observed in the plasma and both muscles under malnourished condition, (3) the energy‐sensing response was observed as AMPK‐independent SIRT1 inhibition in both muscles, and (4) malnutrition decreased the expression of PGC‐1α and PINK1 in both muscles. Here, SIRT1 is linked to nutritional deficiency disease.