Recently, genomic characterizations of ACC expanded the list of known mutations including also those on PRKAR1A (protein kinase cAMP‐dependent regulatory type I alpha), RPL22 (ribosomal protein L22), TERF2 (telomere specific protein 2), CCNE1 (cyclin E1) and NF1 (neurofibromatosis type 1) genes 4 and revealed high heterogeneity and histotype‐specific genomic profiles.5 This evidence concerns the gene RPL22 and adrenal cortex carcinoma.