In particular, we revealed that both sirt1 pharmacological inhibition (sirtinol) and gene silencing reduce proliferation of H295R and SW13 adrenocortical cancer cells by interfering with E2/ERα and IGF1R pathways through the inhibition of several proteins, such as ERα, CCND1 and IGF1R (Figure 6) and activating apoptosis. Here, CCND1 is linked to adrenal cortex carcinoma.