In a routine diagnostic procedure, multiple different criteria will be gathered and analysed; tumour size and grade (Elston and Ellis); presence of lymphovascular invasion; DCIS and LCIS; assessment of surgical margins; the immunohistochemical profile of hormonal receptors (eg oestrogen – ER (most commonly the alpha receptor), progesterone – PR), the HER2 receptor status and analysis of proliferation index, determined with the Ki‐67 (Mib 1) percentage of nuclear expression, is an additional independent prognostic parameter for DFS and OS in BC patients.16 This evidence concerns the gene NR4A1 and breast cancer.