Akt inactivation reduces the degradation of p53, which ultimately leads to the increased expression of p21 and p53, and inhibition of tumor progression, indicating that tanshinone induces apoptosis through the mitochondrial apoptosis pathway and inhibition of the PTEN‐mediated PI3 K/Akt pathway for effectively inhibiting tumor growth.164. The gene discussed is PTEN; the disease is neoplasm.