As a protein with a short half‐life, Mcl‐1 abundance is strictly regulated at many levels, including transcriptional, transcriptional, and post‐translational levels Tan IIA can be used as an EGFR signal inhibitor that targets the EGFR‐Akt‐Mcl1 axis, shortening the Mcl‐1 half‐life and promoting its ubiquitination, which can provide new options for NSCLC therapy.255. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.