TPGS/PEG‐PCL mixed micelle (CK‐M) promotes tumor cell apoptosis and inhibits tumor cell metastasis, invasion, and efflux by regulating levels of Bax, Bcl‐2, matrix metalloproteinase‐2, P‐glycoprotein, caspase‐3, and caspase‐2.141. The gene discussed is BCL2; the disease is neoplasm.