It also enhanced the apoptosis of A549 cells induced by PTX and the anti‐tumor effect on A549 xenografts by increasing the expression of Bax and active cystatin‐3 and decreasing levels of p‐Akt, Bcl‐2, and p‐ERK, while there were no apparent side effects in vivo.44 This evidence concerns the gene AKT1 and neoplasm.