At the same time, the β‐elemene upregulates the expression levels of ER‐related proteins, such as ATF6, PERK, IREα, ATF4, and CHOP, and downregulates the expression of Bcl‐2, which inhibits lung cancer growth and cell viability in a dose‐dependent and time‐dependent manner.133. This evidence concerns the gene DDIT3 and lung cancer.