At the same time, the β‐elemene upregulates the expression levels of ER‐related proteins, such as ATF6, PERK, IREα, ATF4, and CHOP, and downregulates the expression of Bcl‐2, which inhibits lung cancer growth and cell viability in a dose‐dependent and time‐dependent manner.133. The gene discussed is ATF4; the disease is lung carcinoma.