A prognostic index model for chemotherapy‐naïve patients treated with AA‐P has been described, including the following clinical parameters: presence of lymph node metastasis, lactate dehydrogenase (LDH) > upper limits of laboratory normal (ULN), ≥ 10 bone metastasis, hemoglobin (Hb) ≤ lower limits of laboratory normal (LLN), and PSA > 39.5 ng·mL−1 [24]. Here, KLK3 is linked to metastatic malignant neoplasm in the lymph nodes.