KLK3 and metastatic malignant neoplasm in the lymph nodes: In a multivariable Cox regression model, detectable KLK3 mRNA levels and presence of lymph node metastasis were both independent predictors of shorter PFS (HR 5.07; 95% CI 1.81–14.18; P = 0.0020 and HR 2.57; 95% CI 1.20–5.50, P = 0.0149 respectively; Table 3).