DNMT3A and Tatton-Brown-Rahman overgrowth syndrome: In contrast, missense-mutant (Y365C, I310N or W297del) DNMT3A in the PWWP domain, which causes Tatton–Brown–Rahman syndrome (TBRS), a childhood overgrowth disorder, abolishes its binding affinity towards H3K36me2 resulting in aberrant intergenic CpG methylation (Weinberg et al. 2019).