Notably, Chen et al. found shRNA-mediated depletion of CMTM6 down-regulated PD-L1 expression in SCC7 tongue squamous cancer cells, and consequently delayed allograft tumor growth and augmented CD8+ and CD4+ T-cell infiltration, which was accompanied by decrease of PD-1+, TIM-3+, VISTA+, LAG-3+, and B7-H3+ exhausted T cells [7]. The gene discussed is CD274; the disease is neoplasm.