In summary, on the basis of our results, we propose the novel mechanism that downstream activation of IL-17B/IL-17RB signaling activates autophagy, facilitating the self-renewal and tumorigenesis of GC cells, and this novel mechanism involves the recruitment of TRAF6 on the IL-17RB intracellular domain, which promotes direct binding of TRAF6 with Beclin-1 to enhance the K63-mediated ubiquitination of Beclin-1. This evidence concerns the gene IL17RB and gastric cancer.