Our results show that two loci previously implicated in Fuchs endothelial corneal dystrophy (FECD)55 are also associated with keratoconus; the PIDD1/SLC25A22 locus (rs7117921, p = 1.09 × 10−26) and ATP1B1 (rs1200108, p = 4.52 × 10−10). Here, SLC25A22 is linked to Fuchs endothelial corneal dystrophy.