Ndc80 overexpression has previously been described in brain, liver, breast, and lung cancers and increase in total Ndc80 translated into increased accumulation of this protein at the kinetochore in human colorectal carcinoma (HCT116), colorectal adenocarcinoma (HT29), osteosarcoma (U2OS) and cervix adenocarcinoma (HeLa) cells [34, 35]. Here, NDC80 is linked to colorectal adenocarcinoma.