Amplification of DARPP-32 and its truncated isoform t-DARPP has been found in 68% of gastric cancers and several studies indicated that it is also over-expressed in cancers of the breast, prostate, colon, and esophagus—specifically in 30% of esophageal squamous cell carcinomas [37–43]. The gene discussed is PPP1R1B; the disease is esophageal squamous cell carcinoma.