Furthermore, we observed a reduction of Naïve (CD62LhighCD44low) CD8+ T cells and the accumulation of effector memory (CD62LlowCD44high) CD8+ T cells in homeostatic condition (i.e., without any infection) in Opa1fl/fl;Lck-Cre+ mice (Fig. 4E). The gene discussed is CD8A; the disease is infection.