The low discriminative accuracy of the model in SMC (68.8) and EMCI women (71.3), even with the incorporation of APOE \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\varepsilon 4$$\end{document}ε4 status indicates that it is challenging to accurately predict amyloid status in women in early stages of AD. This evidence concerns the gene APOE and Alzheimer disease.