STXBP2, whose encoded product, syntaxin binding protein 2, docks vesicles to membranes46 was increased in AD-PREC, while N-ethylmaleimide-sensitive factor (NSF), a neuronally expressed ATP-ase36 involved in disassembling docked vesicles45 was reduced in AD-PREC. This evidence concerns the gene NSF and Alzheimer disease.