CD274 and neoplasm: Here, an NK cell-targeting imNA was constructed by gently mixing αFc-NP with anti-KLRG1 (killer-cell lectin-like receptor G1) antibody (αKLRG1) and anti-PDL1 antibody (αPDL1); the former could specifically blockade cadherin/KLRG1 interaction and enhance the cytolytic activity and proliferation of NK cells, and the latter can bind to tumor cells.