We finally selected top seven genes with abnormally high expression (C16orf59, GOLM1, IQGAP3, PYCR1, SAPCD2, TOP2A, and UBE2T) and top nine genes with abnormally low expression (EPAS1, SEMA3G, STX11, RGCC, FAM107A, TEK, S1PR1, RTKN2, and OTUD1) in NSCLC whose expression level were closely related to patient OS (Fig. 1A, B and Supplementary Data B). The gene discussed is TOP2A; the disease is non-small cell lung carcinoma.