Acute immunotherapy with IVMP, IVIg and/or PLEX.ICU monitoring for severe dysautonomia.Beta-blockers (eg, propranolol), alpha-2 blockers (eg, clonidine), and/or acetylcholine esterase inhibitors (pyridostigmine) for increased sympathetic drive.Midodrine, fludrocortisone or droxidopa for symptomatic postural hypotension.Temporary pacing for heart block or severe arrhythmia.Total parental nutrition for patients with severe gastrointestinal dysmotility.Anti-muscarinics (eg, oxybutynin) for bladder incontinence. The gene discussed is PSMA2; the disease is Arrhythmia.