CD4 and acute myeloid leukemia: A tumor-bearing mouse model showed tumor-infiltrating Treg cells can be converted from IL17A+FoxP3neg cells fostered by TGFβ and PGE2 [102], which is consistent with our results about two Treg states and development pathways of naïve CD4+ T cell to TH17-like subsets and then Treg subsets in AML patients.