CD4 and acute myeloid leukemia: We acquired the expression data of CD69highCD4+ T population and CD69lowCD4+ T population for UMAP (Fig. 5a), and found a unique cytotoxic CD4+ T subset existed in both AML patients and healthy donors, and CD69low LTBhighCD4+ T subset in AML patients but rarely in healthy donors (Fig. 5b and Fig. 5c) (Table 1).