MRC1 and acute myeloid leukemia: In order to better understand the heterogeneity of monocytes and macrophages within and across AML patients and healthy donors, we extracted and clustered this population (4487 cells) by UMAP (Supplementary Figure 3A), and got 10 subsets (Cluster 0:MS4A6Ahigh subset, Cluster 1:CD163high subset, Cluster 2:MKI67+ subset, Cluster 3:MARCOhigh subset, Cluster 4:FCGR3A+ subset, Cluster 5:MRC1+ subset, Cluster 6:CD14highITGAMhigh subset, Cluster 7:CXCL8high subset, Cluster 8:IL10highTGFB1high subset, and Cluster 9:IFNGhigh subset) (Table 1).