In most AML patients, the proportion of transitional GZMA+GNLYlowGZMK+CD8+ effector T subset (except AML556.D0, AML556.D31,) and GZMAlowGNLY+ cytotoxic T subset (AML314.D0, AML556.D0, AML556.D15, AML556.D31, and AML870.D14), are decreased. Here, CD8A is linked to acute myeloid leukemia.