Under normal conditions, high expression of HMGA1 can occur during embryogenesis and in normal embryonic stem cells and adult stem cells [12, 13] In mature differentiated tissues, HMGA1 is barely detected; however, some ectopic events in cancer, such as oncogenic transcription factors, epigenetic changes, and chromosomal translocation events, can induce abnormal up-regulation of HMGA1 [14]. This evidence concerns the gene HMGA1 and cancer.