Consistently, PCR and western blot analyses showed that both the mRNA and protein levels of YAP1, the main effector of the Hippo signaling pathway, were significantly downregulated in WDR3-silenced pancreatic cancer cells (Fig. 4d-e), while both the mRNA and protein levels of YAP1 were significantly upregulated in WDR3-overexpressing pancreatic cancer cells (Fig. 4f-g). Here, WDR3 is linked to familial pancreatic carcinoma.