From March 9 to March 27, 2020, we analyzed plasma levels of renin, angiotensin I (Ang I), Ang II and Ang 1–7 in 32 consecutive patients with laboratory-confirmed SARS-Cov-2 infection and acute respiratory distress syndrome (ARDS) within 24 h of admission to ICU, approved by the Ethical Committee of Fondazione Policlinico Gemelli. Here, AGT is linked to acute respiratory distress syndrome.