Interestingly, many of these splicing factors (AQR, MFAP1, NHP2L1, PRPF8, SF3B1, SNRPD3 and SNRPF) were identified to affect SCC in the cervical HeLa cancer cell line of which a limited number (NHP2L1, MFAP1 and PRPF8) was linked to sororin alternative splicing [10, 33], suggesting that the regulation of SCC by splicing factors is a common mechanism independent of the cancer type. The gene discussed is SNRPD3; the disease is cancer.